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-synuclein, that's a primary part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that's an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) tension, counsel that dysfunction of the intracellular proteinase programs, for example ubiquitin-proteasome method or lysosomal technique, which removes unnecessary toxic proteins in
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